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Submit ReviewPilocarpine hydrochloride
Description: Muscarinic agonist
Chemical Name: (3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Pilocarpine hydrochloride
Pilocarpine hydrochloride is an M3 muscarinic acetycholine receptor agonist.
Compound Libraries for Pilocarpine hydrochloride
Pilocarpine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Pilocarpine hydrochloride
| M. Wt | 244.72 |
| Formula | C11H16N2O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 54-71-7 |
| PubChem ID | 5909 |
| InChI Key | RNAICSBVACLLGM-GNAZCLTHSA-N |
| Smiles | O=C1[C@@]([H])(CC)[C@](CC2=CN=CN2C)([H])CO1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pilocarpine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.35 | 75 | |
| water | 24.47 | 100 |
Preparing Stock Solutions for Pilocarpine hydrochloride
The following data is based on the product molecular weight 244.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.09 mL | 20.43 mL | 40.86 mL |
| 5 mM | 0.82 mL | 4.09 mL | 8.17 mL |
| 10 mM | 0.41 mL | 2.04 mL | 4.09 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.82 mL |
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Product Datasheets for Pilocarpine hydrochloride
References for Pilocarpine hydrochloride
References are publications that support the biological activity of the product.
ten Berge et al (1996) Differences in the prejunctional effects of methach. and PilC on the release of endogenous acetylcholine from guinea-pig trachea. Naunyn Schmiedebergs Arch.Pharmacol. 354 606 PMID: 8938659
Wang et al (1999) PilC modulates the cellular electrical properties of mammalian hearts by activating a cardiac M3 receptor and a K+ current. Br.J.Pharmacol. 126 1725 PMID: 10372814
Brown and Taylor (1996) Muscarinic receptor agonists and antagonists. The Pharmacological Basis of Therapeutics. Eds Goo Chapter 7, p147
Merck Index 12 7578
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Keywords: Pilocarpine hydrochloride, Pilocarpine hydrochloride supplier, Muscarinic, agonists, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, 0694, Tocris Bioscience
3 Citations for Pilocarpine hydrochloride
Citations are publications that use Tocris products. Selected citations for Pilocarpine hydrochloride include:
Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114
Tallarida et al (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids 42 2521 PMID: 21850438
Overby et al (2014) The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of PilC on outflow facility in mice. Nat Chem Biol 55 3727 PMID: 24833737
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