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Submit ReviewSB 203186 hydrochloride
Description: 5-HT4 antagonist
Chemical Name: 1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for SB 203186 hydrochloride
SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist with high affinity for human atrial 5-HT4 receptors.
Licensing Information
Sold with the permission of GlaxoSmithKline
Technical Data for SB 203186 hydrochloride
| M. Wt | 308.81 |
| Formula | C16H20N2O2.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 207572-69-8 |
| PubChem ID | 9926639 |
| InChI Key | LYMBEMCUJNDSBZ-UHFFFAOYSA-N |
| Smiles | Cl.O=C(OCCN1CCCCC1)C1=CNC2=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SB 203186 hydrochloride
References for SB 203186 hydrochloride
References are publications that support the biological activity of the product.
McLean and Coupar (1995) 5-HT4 receptor antagonist affinities of SB207710, SB205008 and SB 203186 in the human colon, rat oesophagus and guinea-pig ileum peristaltic reflex. Naunyn Schmiedebergs Arch.Pharmacol. 352 132 PMID: 747435
Midhurst and Kaumann et al (1993) Characterisation of 5-HT4 receptor mediating tachycardia in piglet isolated right atrium. Br.J.Pharmacol. 110 1023 PMID: 8298790
Parker et al (1995) Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186. Naunyn Schmiedebergs Arch.Pharmacol. 353 28 PMID: 8750913
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Citations for SB 203186 hydrochloride
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Currently there are no citations for SB 203186 hydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.