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Description: A stable analog of endogenous S-nitroso compounds
Chemical Name: (S)-Nitroso-N-acetylpenicillamine
Biological Activity for SNAP
SNAP is a stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t½ of 37h.
Technical Data for SNAP
| M. Wt | 220.24 |
| Formula | C7H12N2O4S |
| Storage | Store at -20°C |
| CAS Number | 79032-48-7 |
| PubChem ID | 5231 |
| InChI Key | ZIIQCSMRQKCOCT-UHFFFAOYSA-N |
| Smiles | O=NSC(C)(C)C(NC(C)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SNAP
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.02 | 100 |
Preparing Stock Solutions for SNAP
The following data is based on the product molecular weight 220.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.54 mL | 22.7 mL | 45.41 mL |
| 5 mM | 0.91 mL | 4.54 mL | 9.08 mL |
| 10 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.91 mL |
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Product Datasheets for SNAP
References for SNAP
References are publications that support the biological activity of the product.
Bauer and Fung (1991) Differential thermodynamic effects and tolerance properties of nitrogly. and S-nitrosothiol in experimental heart failure. J.Pharmacol.Exp.Ther. 256 249 PMID: 1899118
Cross et al (1994) Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor. Neuropharmacology 33 915 PMID: 7969812
Ekblad and Sundler (1997) Motor responses in rat ileum evoked by nitric oxide donors vs. field stimulation: modulation by pituitary adenylate cyclase-activating peptide, forskolin and guanylate cyclase inhibitors. J.Pharmacol.Exp.Ther. 283 23 PMID: 9336304
Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779 PMID: 10401570
If you know of a relevant reference for SNAP, please let us know.
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Keywords: SNAP, SNAP supplier, stable, endogenous, S-nitroso, ROS, Donors, NO, Precursors, Nitric, Oxide, Signaling, Signalling, /, 0598, Tocris Bioscience
10 Citations for SNAP
Citations are publications that use Tocris products. Selected citations for SNAP include:
Yang (2007) Modulation of inhibitory activity by nitric oxide in the thalamus. J Neurophysiol 97 3386 PMID: 17376843
Rodríguez-Muñoz et al (2011) NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor. Antioxid Redox Signal 14 2413 PMID: 21235400
Cheng et al (2011) Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Lett 585 328 PMID: 21156174
Polter (2017) Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress Elife 6 e23786 PMID: 28402252
Nistri et al (2002) High-Yield Method for Isolation and Culture of Endothelial Cells from Rat Coronary Blood Vessels Suitable for Analysis of Intracellular Calcium and Nitric Oxide Biosynthetic Pathways. Evid Based Complement Alternat Med 4 32 PMID: 12734571
Fedele et al (1996) In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway. Br J Pharmacol 119 590 PMID: 8894183
Sachs et al (2004) Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci U S A 101 3680 PMID: 14990791
Sánchez et al (2014) Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors. Br J Pharmacol 171 5682 PMID: 25091502
Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex 20 982 PMID: 19666830
Sunters et al (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i J Biol Chem 285 8743 PMID: 20042609
Do you know of a great paper that uses SNAP from Tocris? Please let us know.
Reviews for SNAP
Average Rating: 5 (Based on 1 Review.)
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JNK-dependent rescue of LTPGABA by acute norBNI.
By
Anonymous on 03/18/2020
Assay Type: In Vivo
Species: Rat
Cell Line/Tissue: brain
IPSCs used before and 15 min after drug application (SNAP, 400 µM)
