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Sotalol hydrochloride

Cat. No. 0952 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: β antagonist
Chemical Name: N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Sotalol hydrochloride

Sotalol hydrochloride is a relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity.

Technical Data for Sotalol hydrochloride

M. Wt 308.82
Formula C12H20N2O3S.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 959-24-0
PubChem ID 66245
InChI Key VIDRYROWYFWGSY-UHFFFAOYSA-N
Smiles Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sotalol hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 15.44 50

Preparing Stock Solutions for Sotalol hydrochloride

The following data is based on the product molecular weight 308.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.48 mL 32.38 mL 64.76 mL
2.5 mM 1.3 mL 6.48 mL 12.95 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
25 mM 0.13 mL 0.65 mL 1.3 mL

Molarity Calculator

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Product Datasheets for Sotalol hydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Sotalol hydrochloride

References are publications that support the biological activity of the product.

Claudel and Touboul (1995) Sotalol: from 'just another beta blocker' to 'the prototype class III antidysrhythmic compound'. Pacing Clin.Electrophysiol. 18 451 PMID: 7770366

Fiset et al (1997) Block of Iks by the diuretic agent indap. modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol. J.Pharmacol.Exp.Ther. 283 148 PMID: 9336319

Uloth et al (1966) Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines. J.Med.Chem. 9 88 PMID: 6006227

Merck Index 12 8876

If you know of a relevant reference for Sotalol hydrochloride, please let us know.

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3 Citations for Sotalol hydrochloride

Citations are publications that use Tocris products. Selected citations for Sotalol hydrochloride include:

McKeithan et al (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 8 766 PMID: 29075196

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Neurosci 329 350 PMID: 19144685

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572

Do you know of a great paper that uses Sotalol hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.