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Submit Review(-)-Lobeline hydrochloride
Discontinued Product
1077 has been discontinued.
View all Nicotinic Receptors (Non-selective) products.
Description: Nicotinic partial agonist
Chemical Name: 2-[(2R,6S)-6-[(2S)-2-Hydroxyphenethyl)]-1-methyl-2-piperidinyl]acetophenone hydrochloride
Biological Activity for (-)-Lobeline hydrochloride
(-)-Lobeline hydrochloride is a high affinity, partial agonist with a Ki value of 4.4 nM in rat brain.
Technical Data for (-)-Lobeline hydrochloride
| M. Wt | 373.92 |
| Formula | C22H27NO2.HCl |
| Storage | Store at RT |
| CAS Number | 134-63-4 |
| PubChem ID | 11527152 |
| InChI Key | LPMXVESGRSUGHW-VGFRVVOQSA-N |
| Smiles | O[C@H]([C@]2=CC=CC=C2)C[C@@H]1CCC[C@H](CC(C3=CC=CC=C3)=O)N1C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (-)-Lobeline hydrochloride
References for (-)-Lobeline hydrochloride
References are publications that support the biological activity of the product.
Damaj et al (1997) Pharmacology of lobeline, a nicotinic receptor ligand. J.Pharmacol.Exp.Ther. 282 410 PMID: 9223582
Merck Index 12 5580
Farook et al (2009) Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiol.Behav. 97 503 PMID: 19268674
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Keywords: (-)-Lobeline hydrochloride, (-)-Lobeline hydrochloride supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, partial, (Non-selective), 1077, Tocris Bioscience
Citations for (-)-Lobeline hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for (-)-Lobeline hydrochloride.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.