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Submit ReviewSB 205607 dihydrobromide
Description: Selective, high affinity non-peptide δ1 agonist
Alternative Names: TAN 67
Chemical Name: (R*,S*)-(±)-2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aa-octahydroquinolino[2,3,3-g]isoquinoline dihydrobromide
Purity: ≥97% (HPLC)
Biological Activity for SB 205607 dihydrobromide
The first described non-peptide δ1 opioid receptor agonist with very high affinity and selectivity for the δ1 subtype (Ki values are 1.12, 2320 and 1790 nM at δ1, μ and κ receptors respectively).
Licensing Information
Sold under license
Compound Libraries for SB 205607 dihydrobromide
SB 205607 dihydrobromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SB 205607 dihydrobromide
| M. Wt | 506.28 |
| Formula | C23H24N2O.2HBr |
| Storage | Store at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 1217628-73-3 |
| PubChem ID | 56972161 |
| InChI Key | GWXFBFMLKRAWEU-YJKXCHRFSA-N |
| Smiles | [H][C@@](C1)2[C@](CC(N=C(C=CC=C4)C4=C3)=C3C2)([C@]5=CC=CC(O)=C5)CCN1C.Br.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SB 205607 dihydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 50.63 | 100 | |
| DMSO | 50.63 | 100 |
Preparing Stock Solutions for SB 205607 dihydrobromide
The following data is based on the product molecular weight 506.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.88 mL | 19.75 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.95 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets for SB 205607 dihydrobromide
References for SB 205607 dihydrobromide
References are publications that support the biological activity of the product.
Kamei et al (1995) Antinociceptive effects of the selective non-peptidic δ-opioid receptor agonist TAN-67 in diabetic mice. Eur.J.Pharmacol. 276 131 PMID: 7781682
Knap et al (1995) Properties of TAN-67, a non-peptidic β-opioid receptor agonist, at cloned human δ- and μ-opioid receptors. Eur.J.Pharmacol. 291 129 PMID: 8566162
Nagase et al (2001) The pharmacological profile of δ opioid receptor ligands (+) and (-) TAN-67 on pain modulation. Life Sci. 68 2227 PMID: 11358331
Nagase et al (1994) Syntheses of non-peptidic delta opioid agonists and their structure-activity relationships. Jpn.J.Pharmacol. 64 Suppl. 1, 35P
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Keywords: SB 205607 dihydrobromide, SB 205607 dihydrobromide supplier, δ1-opioid, delta1-opioid, selective, high, affinity, non-peptide, agonists, DOP, Receptors, OP1, SB205607, dihydrobromide, TAN67, TAN, 67, Delta, Opioid, 0921, Tocris Bioscience
2 Citations for SB 205607 dihydrobromide
Citations are publications that use Tocris products. Selected citations for SB 205607 dihydrobromide include:
Nielsen et al (2012) The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking. Addict Biol 17 224 PMID: 21309957
Robins et al (2018) Critical Role for Gi/o-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice. Front Psychiatry 9 112 PMID: 29686629
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