Home / Pharmacology / Enzymes / Kinases / Protein Kinase G / Protein Kinase G Inhibitors / Rp-8-Br-PET-cGMPS

Rp-8-Br-PET-cGMPS

Cat. No. 3028 2 Citations 1 Review Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Protein kinase G inhibitor
Chemical Name: 2-Bromo-3,4-dihydro-3-[3,5-O-[(R)-mercaptophosphinylidene]-β-D-ribofuranosyl]-6-phenyl-9H-Imidazo[1,2-a]purin-9-one sodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Rp-8-Br-PET-cGMPS

Rp-8-Br-PET-cGMPS is a competitive, reversible cGMP-dependent protein kinase (PKG) inhibitor; cGMP analog.

This product is sold in units of 560μg, equivalent to 1μmol.

Technical Data for Rp-8-Br-PET-cGMPS

M. Wt 562.27
Formula C18H14BrN5NaO6PS
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 185246-32-6
PubChem ID 23695925
InChI Key PNUXBFRWMZKKAJ-IPZAVTHYSA-M
Smiles [H][C@@]([C@@](O[C@@H](N3C(Br)=NC5=C3NC4=NC(C6=CC=CC=C6)=CN4C5=O)[C@@H]2O)([H])CO1)2O[P@@]1(S[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rp-8-Br-PET-cGMPS

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.25 20
DMSO 22.49 40

Preparing Stock Solutions for Rp-8-Br-PET-cGMPS

The following data is based on the product molecular weight 562.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.4 mM 4.45 mL 22.23 mL 44.46 mL
2 mM 0.89 mL 4.45 mL 8.89 mL
4 mM 0.44 mL 2.22 mL 4.45 mL
20 mM 0.09 mL 0.44 mL 0.89 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Rp-8-Br-PET-cGMPS

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for Rp-8-Br-PET-cGMPS

References are publications that support the biological activity of the product.

Wei et al (1996) Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1,N2-etheno-substituted cGMP analogues as probes of the cGMP-binding site. Biochemistry 35 16815 PMID: 8988020

Qi et al (2007) Protein kinase G regulates the basal tension and plays a major role in nitrovasodilator-induced relaxation of porcine coronary veins. Br.J.Pharmacol. 152 1060 PMID: 17891157

Valtcheva et al (2008) The commonly used cGMP-dependent protein kinase type I (cGKI) inhibitor Rp-8-Br-PET-cGMPS can activate cGKI in vitro and in intact cells. J.Biol.Chem. 284 556 PMID: 19008225

If you know of a relevant reference for Rp-8-Br-PET-cGMPS, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Protein Kinase G Inhibitors

Keywords: Rp-8-Br-PET-cGMPS, Rp-8-Br-PET-cGMPS supplier, Protein, kinase, G, inhibitors, inhibits, PKG, Kinases, cGMP-dependent, Kinase, 3028, Tocris Bioscience

2 Citations for Rp-8-Br-PET-cGMPS

Citations are publications that use Tocris products. Selected citations for Rp-8-Br-PET-cGMPS include:

Berlinguer-Palmini et al (2013) GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One 8 e82180 PMID: 24312407

Lin et al (2008) Integrin regulation of cytoplasmic calcium in excitatory neurons depends upon glutamate receptors and release from intracellular stores. Cell 37 770 PMID: 18289871

Do you know of a great paper that uses Rp-8-Br-PET-cGMPS from Tocris? Please let us know.

Reviews for Rp-8-Br-PET-cGMPS

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Rp-8-Br-PET-cGMPS?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


PKG inhibitor in vitro.
By Anonymous on 08/11/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Neuron

Used in cultured neurons at 10 uM

Excellent PKG inhibitor

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.