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Submit ReviewTiotidine
Description: Potent and selective H2 antagonist
Alternative Names: ICI 125,211
Purity: ≥98% (HPLC)
Biological Activity for Tiotidine
Tiotidine is a potent histamine H2-receptor antagonist with negligible activity against H1- and H3- receptors.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for Tiotidine
| M. Wt | 312.41 |
| Formula | C10H16N8S2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 69014-14-8 |
| PubChem ID | 50287 |
| InChI Key | YDDXVAXDYKBWDX-UHFFFAOYSA-N |
| Smiles | CN\C(NCCSCC1=CSC(\N=C(/N)N)=N1)=N/C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tiotidine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 10 | ||
| DMSO | 100 |
Preparing Stock Solutions for Tiotidine
The following data is based on the product molecular weight 312.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.2 mL | 16 mL | 32.01 mL |
| 5 mM | 0.64 mL | 3.2 mL | 6.4 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.2 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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Product Datasheets for Tiotidine
References for Tiotidine
References are publications that support the biological activity of the product.
Hill (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693
Trzeciakowski and Levi (1980) The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H2- receptor antagonist. J.Pharmacol.Exp.Ther. 214 629 PMID: 6105207
Yellin et al (1979) ICI 125,211: A new gastric antisecretory agent acting on histamine H2- receptors. Life Sci. 25 2001 PMID: 43449
If you know of a relevant reference for Tiotidine, please let us know.
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Keywords: Tiotidine, Tiotidine supplier, Potent, selective, H2, antagonists, Receptors, Histamine, histaminergic, AstraZeneca, ICI125211, ICI, 125,211, 0826, Tocris Bioscience
5 Citations for Tiotidine
Citations are publications that use Tocris products. Selected citations for Tiotidine include:
Chigaev et al (2011) Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4. J Biol Chem 286 20375 PMID: 21515675
Alonso et al (2015) Physiological implications of biased signaling at histamine H2 receptors. Exp Ther Med 6 45 PMID: 25805997
Nagata et al (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep 9 16438 PMID: 31712714
Flamand et al (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol 141 552 PMID: 14744809
Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Front Pharmacol 152 891 PMID: 17891168
Do you know of a great paper that uses Tiotidine from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.