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Submit ReviewValerenic acid
Description: Positive allosteric modulator of GABAA receptors
Chemical Name: (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-Hexadydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoic acid
Purity: ≥99% (HPLC)
Biological Activity for Valerenic acid
Valerenic acid is a positive allosteric modulator of GABAA receptors that displays preference for receptors containing β2 or β3 subunits. Directly activates the receptor and blocks the channel at high concentrations. Displays sedative, anticonvulsant and anxiolytic activity in vivo. Also acts as a partial agonist of 5-HT5A receptors.
Technical Data for Valerenic acid
| M. Wt | 234.33 |
| Formula | C15H22O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 3569-10-6 |
| PubChem ID | 6440940 |
| InChI Key | FEBNTWHYQKGEIQ-SUKRRCERSA-N |
| Smiles | C[C@@H]2CC[C@@H](/C=C(C(O)=O)\C)C1=C(C)CC[C@@]12[H] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Valerenic acid
References for Valerenic acid
References are publications that support the biological activity of the product.
Dietz et al (2005) Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res.Mol.Brain Res. 138 191 PMID: 15921820
Benke et al (2008) GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology 56 174 PMID: 18602406
Khom et al (2007) Valerenic acid potentiates and inhibits GABAA receptors: molecular mechanism and subunit specificity. Neuropharmacol. 53 178 PMID: 17585957
Khom et al (2016) Analysis of β-subunit-dependent GABAA receptor modulation and behavioral effects of valerenic acid derivatives. J.Pharmacol.Exp.Ther. 357 580 PMID: 27190170
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Keywords: Valerenic acid, Valerenic acid supplier, Positive, allosteric, modulators, GABAA, receptors, Receptors, PAM, 3048, Tocris Bioscience
Citations for Valerenic acid
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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