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Submit ReviewTamsulosin hydrochloride
Description: Selective α1A antagonist
Chemical Name: 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Tamsulosin hydrochloride
Tamsulosin hydrochloride is a selective α1A-adrenoceptor antagonist (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Decreases resting maximal urethral pressure with negligible effect on mean arterial blood pressure in vivo.
Compound Libraries for Tamsulosin hydrochloride
Tamsulosin hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Tamsulosin hydrochloride
| M. Wt | 444.97 |
| Formula | C20H28N2O5S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 106463-17-6 |
| PubChem ID | 5362376 |
| InChI Key | ZZIZZTHXZRDOFM-XFULWGLBSA-N |
| Smiles | C[C@@H](NCCOC2=CC=CC=C2OCC)CC1=CC=C(OC)C(S(=O)(N)=O)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tamsulosin hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.45 | 10 | |
| DMSO | 44.5 | 100 |
Preparing Stock Solutions for Tamsulosin hydrochloride
The following data is based on the product molecular weight 444.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.25 mL | 11.24 mL | 22.47 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.49 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.25 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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Product Datasheets for Tamsulosin hydrochloride
References for Tamsulosin hydrochloride
References are publications that support the biological activity of the product.
Garcia-Sainz et al (1995) Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species. Eur.J.Pharmacol. 289 1 PMID: 7781702
Taguchi et al (1997) Effects of tamsu. metabolites at alpha-1 adrenoceptor subtypes. J.Pharmacol.Exp.Ther. 280 1 PMID: 8996174
Ohtake et al (2005) Effects of tamsu. on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J.Pharm.Pharmacol. 58 345 PMID: 16536901
If you know of a relevant reference for Tamsulosin hydrochloride, please let us know.
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Keywords: Tamsulosin hydrochloride, Tamsulosin hydrochloride supplier, Selective, α1A-adrenoceptor, alpha1A-adrenoceptor, a1a-adrenoceptor, α1a-adrenergic, alpha1a-adrenergic, a1a-adrenergic, antagonists, Receptors, Adrenergic, Alpha-1, 3050, Tocris Bioscience
3 Citations for Tamsulosin hydrochloride
Citations are publications that use Tocris products. Selected citations for Tamsulosin hydrochloride include:
Kunit et al (2014) Inhibition of smooth muscle force generation by focal adhesion kinase inhibitors in the hyperplastic human prostate. Am J Physiol Renal Physiol 307 F823 PMID: 25056351
Xiao et al (2019) Acute tobacco smoke exposure exacerbates the inflammatory response to corneal wounds in mice via the sympathetic nervous system. Commun Biol 2 33 PMID: 30701198
Trevisani et al (2005) Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways. Br J Pharmacol 145 1123 PMID: 15937520
Do you know of a great paper that uses Tamsulosin hydrochloride from Tocris? Please let us know.
Reviews for Tamsulosin hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Used to investigate cell metabolism.
By
Anonymous on 01/27/2023
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Primary hippocampal neurons
The drug was incubated at 10 μM to investigate a potential effect on cell metabolism.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.