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Description: Hsp90 inhibitor
Chemical Name: (15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin
Biological Activity for Macbecin I
Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 activity (IC50 = 2 μM) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC50 ~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (Cat. No. 1368).
Technical Data for Macbecin I
| M. Wt | 558.67 |
| Formula | C30H42N2O8 |
| Storage | Desiccate at -20°C |
| CAS Number | 73341-72-7 |
| PubChem ID | 6436263 |
| InChI Key | PLTGBUPHJAKFMA-HXUNTIRESA-N |
| Smiles | O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](C)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Macbecin I
References for Macbecin I
References are publications that support the biological activity of the product.
Ono et al (1982) Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I. Gann. 73 938 PMID: 6186564
Uehara et al (2003) Natural product origins of Hsp90 inhibitors. Curr.Cancer Drug Targets 3 325 PMID: 14529384
Martin et al (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. J.Med.Chem. 51 2853 PMID: 18357975
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Keywords: Macbecin I, Macbecin I supplier, Hsp90, inhibitors, inhibits, Heat, Shock, Protein, 90, MacbecinI, antibiotics, Antibiotics, 3061, Tocris Bioscience
1 Citation for Macbecin I
Citations are publications that use Tocris products. Selected citations for Macbecin I include:
Alford and Brandman (2018) Quantification of Hsp90 availability reveals differential coupling to the heat shock response. J Cell Biol 217 3809 PMID: 30131327
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Literature in this Area
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
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