Home / Pharmacology / Enzymes / Kinases / Src Kinases / Src Kinase Inhibitors / 1-Naphthyl PP1

1-Naphthyl PP1

Cat. No. 3063 6 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Src family kinase inhibitor; also inhibits c-Abl
Alternative Names: 1-NA-PP 1
Chemical Name: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for 1-Naphthyl PP1

1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

Compound Libraries for 1-Naphthyl PP1

1-Naphthyl PP1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for 1-Naphthyl PP1

M. Wt 317.39
Formula C19H19N5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 221243-82-9
PubChem ID 4877
InChI Key XSHQBIXMLULFEV-UHFFFAOYSA-N
Smiles NC1=NC=NC2=C1C(C3=C4C(C=CC=C4)=CC=C3)=NN2C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 1-Naphthyl PP1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.35 20

Preparing Stock Solutions for 1-Naphthyl PP1

The following data is based on the product molecular weight 317.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.75 mL 78.77 mL 157.53 mL
1 mM 3.15 mL 15.75 mL 31.51 mL
2 mM 1.58 mL 7.88 mL 15.75 mL
10 mM 0.32 mL 1.58 mL 3.15 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for 1-Naphthyl PP1

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for 1-Naphthyl PP1

References are publications that support the biological activity of the product.

Bishop et al (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 395 PMID: 11014197

Bishop et al (1999) Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc. 121 627

If you know of a relevant reference for 1-Naphthyl PP1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Src Kinase Inhibitors

Keywords: 1-Naphthyl PP1, 1-Naphthyl PP1 supplier, Src, family, kinase, inhibits, inhibitors, c-Abl, v-Src, c-Fyn, 1-NaphthylPP1, 1NAPP1, 1-NA-PP, 1, Kinases, Abl, Kinase, 3063, Tocris Bioscience

6 Citations for 1-Naphthyl PP1

Citations are publications that use Tocris products. Selected citations for 1-Naphthyl PP1 include:

O'Neill et al (2016) Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol 215 217 PMID: 27810913

Meyer et al (2015) Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae. Genes Dev 26 2986 PMID: 26157162

Lo and Hollingsworth (2011) Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1. Methods Mol Biol 745 135 PMID: 21660693

Chen et al (2015) Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis. PLoS Biol 13 e1002329 PMID: 26682552

Do you know of a great paper that uses 1-Naphthyl PP1 from Tocris? Please let us know.

Reviews for 1-Naphthyl PP1

There are currently no reviews for this product. Be the first to review 1-Naphthyl PP1 and earn rewards!

Have you used 1-Naphthyl PP1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review