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Submit ReviewDesipramine hydrochloride
Description: Selective inhibitor of noradrenalin transporters
Chemical Name: 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Desipramine hydrochloride
Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).
Technical Data for Desipramine hydrochloride
| M. Wt | 302.84 |
| Formula | C18H22N2.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 58-28-6 |
| PubChem ID | 65327 |
| InChI Key | XAEWZDYWZHIUCT-UHFFFAOYSA-N |
| Smiles | CNCCCN2C1=CC=CC=C1CCC3=C2C=CC=C3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Desipramine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.28 | 100 |
Preparing Stock Solutions for Desipramine hydrochloride
The following data is based on the product molecular weight 302.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.3 mL | 16.51 mL | 33.02 mL |
| 5 mM | 0.66 mL | 3.3 mL | 6.6 mL |
| 10 mM | 0.33 mL | 1.65 mL | 3.3 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets for Desipramine hydrochloride
References for Desipramine hydrochloride
References are publications that support the biological activity of the product.
Torres et al (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 4 13 PMID: 12511858
Zhao et al (2008) NE transporter regulation mediates the long-term behavioral effects of the antidepressant desipr. Neuropsychopharmacol. 33 3190
If you know of a relevant reference for Desipramine hydrochloride, please let us know.
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Keywords: Desipramine hydrochloride, Desipramine hydrochloride supplier, Selective, inhibitors, inhibits, noradrenaline, transporters, Transporter, NET, Adrenergic, Monoamine, Neurotransmitter, Transporters, 3067, Tocris Bioscience
8 Citations for Desipramine hydrochloride
Citations are publications that use Tocris products. Selected citations for Desipramine hydrochloride include:
Choi et al (2013) Changes in c-Fos Expression in the Forced Swimming Test: Common and Distinct Modulation in Rat Brain by desipr. and cital. Korean J Physiol Pharmacol 17 321 PMID: 23946692
Tanaka et al (2018) A mesocortical DA circuit enables the cultural transmission of vocal behaviour. Nature 563 117 PMID: 30333629
Chou et al (2018) (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology 139 1 PMID: 29953886
LaRocca et al (2015) CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis. Neuropsychopharmacology 6 e1773 PMID: 26018734
Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Proc Natl Acad Sci U S A 40 766 PMID: 25249058
Bucher et al (2014) Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037
Yuen et al (2014) Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons. J Biol Chem 289 25177 PMID: 25056951
Kramer et al (2018) Combinatorial Expression of Grp and Neurod6 Defines DA Neuron Populations with Distinct Projection Patterns and Disease Vulnerability. Eneuro 5 PMID: 30135866
Do you know of a great paper that uses Desipramine hydrochloride from Tocris? Please let us know.
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