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Submit ReviewAG 18
Description: EGFR/PDGFR-kinase inhibitor
Alternative Names: RG-50810,Tyrphostin A23
Chemical Name: [(3,4-Dihydroxyphenyl)methylene]-propenedinitrile
Biological Activity for AG 18
AG 18 is an inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC50 values are 35 and 25 μM respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.
Technical Data for AG 18
| M. Wt | 186.17 |
| Formula | C10H6N2O2 |
| Storage | Desiccate at +4°C |
| CAS Number | 118409-57-7 |
| PubChem ID | 2052 |
| InChI Key | VTJXFTPMFYAJJU-UHFFFAOYSA-N |
| Smiles | OC1=C(O)C=C(\C=C(/C#N)C#N)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AG 18
References for AG 18
References are publications that support the biological activity of the product.
Gazit et al (1988) Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242 933 PMID: 3263702
Gazit et al (1989) Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J.Biol.Chem. 264 14503 PMID: 2788167
Gazit et al (1989) Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344 PMID: 2552117
Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782 PMID: 7892601
Soltoff (2004) Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J.Biol.Chem. 279 10910 PMID: 14688271
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Keywords: AG 18, AG 18 supplier, EGFR, PDGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Tyrosine, Kinases, RTKs, Platelet, Derived, AG18, RG50810, RG-50810, Tyrphostin, A23, 0493, Tocris Bioscience
1 Citation for AG 18
Citations are publications that use Tocris products. Selected citations for AG 18 include:
Villalba et al (2007) Contribution of both Ca2+ entry and Ca2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries. Am J Physiol Heart Circ Physiol 292 H1157 PMID: 17085536
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