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Submit ReviewAG 99
Description: EGFR-kinase inhibitor
Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenamide
Purity: ≥99% (HPLC)
Biological Activity for AG 99
AG 99 is an epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 10 μM) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro.
Technical Data for AG 99
| M. Wt | 204.18 |
| Formula | C10H8N2O3 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 122520-85-8 |
| PubChem ID | 5328768 |
| InChI Key | USOXQZNJFMKTKJ-XVNBXDOJSA-N |
| Smiles | NC(=O)C(=C\C1=CC(O)=C(O)C=C1)\C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AG 99
References for AG 99
References are publications that support the biological activity of the product.
Gazit et al (1989) Tyrphostins. I. Synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344 PMID: 2552117
Gazit (1996) Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrphostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J.Med.Chem. 39 4905 PMID: 8960549
Levitzki and Gilon (1991) Tyrphostins as molecular tools and potential antiproliferative drugs. TiPS 12 171 PMID: 1862529
Yamamoto et al (2006) Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J.Cell Sci. 119 4623 PMID: 17062641
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Keywords: AG 99, AG 99 supplier, EGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, AG99, 0497, Tocris Bioscience
Citations for AG 99
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