Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAG 555
Description: Potent EGFR-kinase inhibitor
Alternative Names: Tyrphostin AG 555
Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-2-propenamide
Purity: ≥99% (HPLC)
Biological Activity for AG 555
AG 555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G1 growth arrest selectively in transformed cells (IC50 values are 6.4 and 9.4 μM in HPV16-immortalized and normal keratinocytes respectively).
Technical Data for AG 555
| M. Wt | 322.36 |
| Formula | C19H18N2O3 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 133550-34-2 |
| PubChem ID | 5328770 |
| InChI Key | GSQOBTOAOGXIFL-LFIBNONCSA-N |
| Smiles | OC1=CC=C(\C=C(/C#N)C(=O)NCCCC2=CC=CC=C2)C=C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AG 555
References for AG 555
References are publications that support the biological activity of the product.
Ben-Bassat et al (1999) Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J.Pharmacol.Exp.Ther. 290 1442 PMID: 10454524
Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896 PMID: 1676428
Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782 PMID: 7892601
View Related Products by Target
View Related Products by Product Action
Keywords: AG 555, AG 555 supplier, Potent, EGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Tyrosine, Kinases, RTKs, AG555, Tyrphostin, AG, 555, 0618, Tocris Bioscience
Citations for AG 555
Citations are publications that use Tocris products.
Currently there are no citations for AG 555.
Reviews for AG 555
There are currently no reviews for this product. Be the first to review AG 555 and earn rewards!
Have you used AG 555?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.