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Description: Potent EGFR-kinase inhibitor
Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide
Biological Activity for AG 494
AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.7 μM). Selective over ErbB2, PDGFR and insulin receptor kinase (IC50 values are 42, 6 and > 100 μM respectively).
Technical Data for AG 494
| M. Wt | 280.28 |
| Formula | C16H12N2O3 |
| Storage | Desiccate at +4°C |
| CAS Number | 133550-35-3 |
| PubChem ID | 5328771 |
| InChI Key | HKHOVJYOELRGMV-XYOKQWHBSA-N |
| Smiles | OC1=C(O)C=C(\C=C(/C#N)C(=O)NC2=CC=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AG 494
References for AG 494
References are publications that support the biological activity of the product.
Ben-Bassat et al (1999) Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J.Pharmacol.Exp.Ther. 290 1442 PMID: 10454524
Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896 PMID: 1676428
Tomlins et al (2005) Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts. Exp.Cell Res. 308 439 PMID: 15950968
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Keywords: AG 494, AG 494 supplier, Potent, EGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Tyrosine, Kinases, RTKs, AG494, 0619, Tocris Bioscience
Citations for AG 494
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