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Submit ReviewBW-B 70C
Description: 5-Lipoxygenase inhibitor
Chemical Name: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea
Purity: ≥98% (HPLC)
Biological Activity for BW-B 70C
BW-B 70C is a potent and selective inhibitor of 5-lipoxygenase. Long half-life and high oral bioavailability in vivo.
Technical Data for BW-B 70C
| M. Wt | 316.33 |
| Formula | C17H17FN2O3 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 134470-38-5 |
| PubChem ID | 5353454 |
| InChI Key | UAIYNMRLUHHRMF-AATRIKPKSA-N |
| Smiles | CC(\C=C\C1=CC(OC2=CC=C(F)C=C2)=CC=C1)N(O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BW-B 70C
References for BW-B 70C
References are publications that support the biological activity of the product.
Payne et al (1991) Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 34 189 PMID: 1793063
Salmon et al (1990) Inhibition of 5-lipoxygenase: development of hydroxamic acids and hydroxyureas as potential therapeutic agents. Adv.Prost.Throm.Leuk.Res. 21 109 PMID: 1847758
Yeadon et al (1993) Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions 38 8 PMID: 8480540
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Keywords: BW-B 70C, BW-B 70C supplier, 5-lipoxygenase, inhibitors, oxygenases, inhibits, oxidases, BWB70C, 5-LOX, Lipoxygenase, 1304, Tocris Bioscience
1 Citation for BW-B 70C
Citations are publications that use Tocris products. Selected citations for BW-B 70C include:
Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Cell Biol 153 2031 PMID: 22633978
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