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Description: EGFR-kinase inhibitor
Alternative Names: Tyrphostin AG 556
Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide
Purity: ≥99% (HPLC)
Biological Activity for AG 556
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 1.1 μM). Selective over ErbB2 (IC50 > 500 μM).
Technical Data for AG 556
| M. Wt | 336.39 |
| Formula | C20H20N2O3 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 133550-41-1 |
| PubChem ID | 5328775 |
| InChI Key | GWCNJMUSWLTSCW-SFQUDFHCSA-N |
| Smiles | OC1=C(O)C=C(\C=C(/C#N)C(=O)NCCCCC2=CC=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AG 556
References for AG 556
References are publications that support the biological activity of the product.
Gamett et al (1997) Secondary dimerization between members of the epidermal growth factor receptor family. J.Biol.Chem. 272 12052 PMID: 9115272
Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896 PMID: 1676428
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Keywords: AG 556, AG 556 supplier, EGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, AG556, Tyrphostin, AG, 556, 0616, Tocris Bioscience
Citations for AG 556
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Currently there are no citations for AG 556.
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