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Submit Review(R)-Baclofen
Description: Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)
Alternative Names: STX 209
Chemical Name: (R)-4-Amino-3-(4-chlorophenyl)butanoic acid
Purity: ≥99% (HPLC)
Biological Activity for (R)-Baclofen
More active enantiomer of (RS)-Baclofen, a selective GABAB agonist.
Racemate also available.
Technical Data for (R)-Baclofen
| M. Wt | 213.66 |
| Formula | C10H12ClNO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 69308-37-8 |
| PubChem ID | 44602 |
| InChI Key | KPYSYYIEGFHWSV-QMMMGPOBSA-N |
| Smiles | NC[C@@](CC(O)=O)([H])C1=CC=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (R)-Baclofen
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.27 | 20 with gentle warming |
Preparing Stock Solutions for (R)-Baclofen
The following data is based on the product molecular weight 213.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 23.4 mL | 117.01 mL | 234.02 mL |
| 1 mM | 4.68 mL | 23.4 mL | 46.8 mL |
| 2 mM | 2.34 mL | 11.7 mL | 23.4 mL |
| 10 mM | 0.47 mL | 2.34 mL | 4.68 mL |
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Product Datasheets for (R)-Baclofen
References for (R)-Baclofen
References are publications that support the biological activity of the product.
Falch et al (1986) Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J.Neurochem. 47 898 PMID: 3016189
Hong et al (1991) Effects of phaclofen and the enantiomers of bac. on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur.J.Pharmacol. 196 267 PMID: 1654254
If you know of a relevant reference for (R)-Baclofen, please let us know.
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Keywords: (R)-Baclofen, (R)-Baclofen supplier, Selective, GABAB, agonists, Receptors, STX209, STX, 209, 0796, Tocris Bioscience
14 Citations for (R)-Baclofen
Citations are publications that use Tocris products. Selected citations for (R)-Baclofen include:
Hensler et al (2012) GABAB receptor-positive modulators: brain region-dependent effects. J Pharmacol Exp Ther 340 19 PMID: 21954301
Lobb et al (2010) A dynamic role for GABA receptors on the firing pattern of midbrain DArgic neurons. J Neurophysiol 104 403 PMID: 20445035
Bartoi et al (2010) GABAB receptor constituents revealed by tandem affinity purification from transgenic mice. J Biol Chem 285 20625 PMID: 20406808
Pacey et al (2011) Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. Sci Rep 338 897 PMID: 21636656
Bragina et al (2015) Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci 9 345 PMID: 26388733
Chai et al (2017) Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron 95 531 PMID: 28712653
Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968 PMID: 24971996
Messer and Levine (2012) Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity. J Neurosci Res 90 1454 PMID: 22388975
Klug et al (2012) Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. PLoS One 7 e45323 PMID: 23028932
Styr et al (2019) Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron 102 1009 PMID: 31047779
Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Front Cell Neurosci 5 10468 PMID: 26020477
Wang et al (2015) Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA. Mol Cell Neurosci 9 188 PMID: 26041994
Kirwan et al (2015) Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro. J Pharmacol Exp Ther 142 3178 PMID: 26395144
Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038 PMID: 15210585
Do you know of a great paper that uses (R)-Baclofen from Tocris? Please let us know.
Reviews for (R)-Baclofen
Average Rating: 4 (Based on 1 Review.)
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GABAb specific agonist.
By
Anonymous on 10/22/2018
Assay Type: Ex Vivo
Species: Mouse
Used to activate GABAb, direct application. Although it did not trigger any response, neither did GABA and this was expected, used it to confirm GABAb is not involved in our assay.
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