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Submit Review(+)-U-50488 hydrochloride
Description: Selective κ agonist; less active enantiomer of (±)-U-50488 (Cat. No. 0495)
Chemical Name: trans-(+)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for (+)-U-50488 hydrochloride
(+)-U-50488 hydrochloride is a less active enantiomer of (±)-U-50488.
Racemate and (-)-enantiomer also available.
Technical Data for (+)-U-50488 hydrochloride
| M. Wt | 405.79 |
| Formula | C19H26Cl2N2O.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 114528-81-3 |
| PubChem ID | 6918162 |
| InChI Key | KGMMGVIYOHGOKQ-JAXOOIEVSA-N |
| Smiles | O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@H]1[C@H](N2CCCC2)CCCC1)C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (+)-U-50488 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 40.58 | 100 | |
| DMSO | 40.58 | 100 |
Preparing Stock Solutions for (+)-U-50488 hydrochloride
The following data is based on the product molecular weight 405.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.32 mL | 24.64 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.93 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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Product Datasheets for (+)-U-50488 hydrochloride
References for (+)-U-50488 hydrochloride
References are publications that support the biological activity of the product.
De Costa et al (1987) Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 223 335 PMID: 2822490
If you know of a relevant reference for (+)-U-50488 hydrochloride, please let us know.
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Keywords: (+)-U-50488 hydrochloride, (+)-U-50488 hydrochloride supplier, selective, agonists, enantiomer, κ-opioid, kappa-opioid, KOP, Receptors, OP2, Kappa, Opioid, 0471, Tocris Bioscience
Citations for (+)-U-50488 hydrochloride
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Currently there are no citations for (+)-U-50488 hydrochloride. Do you know of a great paper that uses (+)-U-50488 hydrochloride from Tocris? Please let us know.
Reviews for (+)-U-50488 hydrochloride
Average Rating: 4 (Based on 1 Review.)
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Good product.
By
Luca Zangrandi on 03/05/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: CHO
Successfully induced ERK phosphorylation in CHO cells. Somehow weaker signal compared to other enantiomer.
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