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Submit Review(-)-U-50488 hydrochloride
Description: Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)
Chemical Name: trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for (-)-U-50488 hydrochloride
(-)-U-50488 hydrochloride is a more active enantiomer of (±)-U-50488.
Racemate and (+)-enantiomer also available.
Technical Data for (-)-U-50488 hydrochloride
| M. Wt | 405.79 |
| Formula | C19H26Cl2N2O.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 114528-79-9 |
| PubChem ID | 9931141 |
| InChI Key | KGMMGVIYOHGOKQ-APTPAJQOSA-N |
| Smiles | O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@@H]1[C@@H](N2CCCC2)CCCC1)C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (-)-U-50488 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 | ||
| DMSO | 40.58 | 100 |
Preparing Stock Solutions for (-)-U-50488 hydrochloride
The following data is based on the product molecular weight 405.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.32 mL | 24.64 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.93 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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Product Datasheets for (-)-U-50488 hydrochloride
References for (-)-U-50488 hydrochloride
References are publications that support the biological activity of the product.
De Costa et al (1987) Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 223 335 PMID: 2822490
Morrone et al (1993) Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors. Br.J.Pharmacol. 109 48 PMID: 8388301
Reddy and Bhargava (1993) Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central DA (D2) receptors of the rat. Eur.J.Pharmacol. 235 23 PMID: 8390939
Zhu et al (1998) Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 285 28 PMID: 9535991
If you know of a relevant reference for (-)-U-50488 hydrochloride, please let us know.
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Keywords: (-)-U-50488 hydrochloride, (-)-U-50488 hydrochloride supplier, selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, Kappa, Opioid, 0496, Tocris Bioscience
1 Citation for (-)-U-50488 hydrochloride
Citations are publications that use Tocris products. Selected citations for (-)-U-50488 hydrochloride include:
Pirino et al (2020) Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis Neuropharmacology 181 108341 PMID: 33011200
Do you know of a great paper that uses (-)-U-50488 hydrochloride from Tocris? Please let us know.
Reviews for (-)-U-50488 hydrochloride
Average Rating: 5 (Based on 2 Reviews.)
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Presto-Tango.
By
Anonymous on 06/15/2021
Assay Type: In Vitro
Species: Human
Dose response curve of beta arrestin recruitment
Works very well.
By
Luca Zangrandi on 03/05/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: CHO
Agonist-induced ERK phosphorylation in CHO cells.
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