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Submit Review(+)-UH 232 maleate
Description: D2 autoreceptor antagonist. Also D3 partial agonist
Chemical Name: cis-(+)-5-Methoxy-1-methyl-2-(di-N-propylamino)tetralin maleate
Biological Activity for (+)-UH 232 maleate
(+)-UH 232 maleate is a D2 antagonist (Ki = 72.7 nM in a ligand binding assay; apparent KB = 14.5 nM in a cAMP accumulation assay); displays preferential activity at central dopamine autoreceptors. Stimulates a marked acceleration of dopamine synthesis and turnover. Produces locomotor stimulation. Exhibits little or no activity at central noradrenalin and 5-HT receptors. Also D3 partial agonist.
Technical Data for (+)-UH 232 maleate
| M. Wt | 391.51 |
| Formula | C18H29NO.C4H4O4 |
| Storage | Store at RT |
| CAS Number | 1217473-50-1 |
| PubChem ID | 46830250 |
| InChI Key | MEQAJDYHKYAPJE-GUUGRXDUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.CCCN(CCC)[C@@H]1CCC2=C(C=CC=C2OC)[C@@H]1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (+)-UH 232 maleate
Certificate of Analysis is currently unavailable on-line.
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References for (+)-UH 232 maleate
References are publications that support the biological activity of the product.
Griffon et al (1995) The preferential DA D3 receptor ligand, (+)-UH 232, is a partial agonist. Eur.J.Pharmacol. 282 R3 PMID: 7498261
Hall and Strange (1997) Evidence that antipsychotic drugs are inverse agonists at D2 DA receptors. Br. J. Pharmacol. 121 731 PMID: 9208141
Johansson et al (1985) Novel DA receptor agonists and antagonists with preferential action on autoreceptors. J.Med.Chem. 28 1049 PMID: 3927002
Svensson et al (1986) (+)-AJ 76 and (+)-UH 232: central stimulants acting as preferential DA autoreceptor antagonists. Naunyn Schmiedebergs Arch.Pharmacol. 334 234 PMID: 2880302
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Citations for (+)-UH 232 maleate
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Parkinson's Disease Poster
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