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Submit ReviewW-5 hydrochloride
Description: Calmodulin antagonist
Chemical Name: N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride
Biological Activity for W-5 hydrochloride
W-5 hydrochloride is a calmodulin antagonist (inhibits Ca2+-calmodulin dependent PDE with an IC50 of 240 μM).
Technical Data for W-5 hydrochloride
| M. Wt | 342.88 |
| Formula | C16H22N2O2S.HCl |
| Storage | Store at RT |
| CAS Number | 61714-25-8 |
| PubChem ID | 173829 |
| InChI Key | HOCSVIGHWPLMFC-UHFFFAOYSA-N |
| Smiles | Cl.NCCCCCCNS(=O)(=O)C1=C2C=CC=CC2=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for W-5 hydrochloride
References for W-5 hydrochloride
References are publications that support the biological activity of the product.
Hidaka et al (1981) Activity-structure relationship of calmodulin antagonists. Naphthalenesulfonamide derivatives. Mol.Pharmacol. 20 571 PMID: 7329399
Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588
Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736
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Keywords: W-5 hydrochloride, W-5 hydrochloride supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, 0368, Tocris Bioscience
1 Citation for W-5 hydrochloride
Citations are publications that use Tocris products. Selected citations for W-5 hydrochloride include:
Long et al (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. PLoS Biol 284 8726 PMID: 19141616
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