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Submit ReviewButabindide oxalate
Description: High affinity CCK-inactivating serine protease inhibitor
Chemical Name: (2S)-[1-[(2S)-2-amino-1-oxobutyl]-N-butyl]-2,3-dihydro-1H-indole-2-carboxamide oxalate
Purity: ≥99% (HPLC)
Biological Activity for Butabindide oxalate
Butabindide oxalate is a high affinity, reversible, selective and competitive inhibitor of a CCK-inactivating serine protease (tripeptidyl peptidase II) (Ki = 7 nM). Active in vivo (ID50 = 1.1 and 6.8 mg/kg i.v. for inhibition of liver and brain enzyme respectively).
Licensing Information
Sold with the permission of INSERM and UCL
Technical Data for Butabindide oxalate
| M. Wt | 393.44 |
| Formula | C17H25N3O2.C2H2O4 |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 185213-03-0 |
| PubChem ID | 56972132 |
| InChI Key | KKMJFDVOXSGHBF-SLHAJLBXSA-N |
| Smiles | O=C(O)C(O)=O.O=[C@]([C@@H](N)CC)N([C@H]([C@@](NCCCC)=O)C2)C1=C2C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Butabindide oxalate
References for Butabindide oxalate
References are publications that support the biological activity of the product.
Ganellin et al (2000) Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J.Med.Chem. 43 664 PMID: 10691692
Renn et al (1998) Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. J.Biol.Chem. 273 19173 PMID: 9668104
Rose et al (1996) Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature 380 403 PMID: 8602240
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Keywords: Butabindide oxalate, Butabindide oxalate supplier, CCK-inactivating, serine, protease, inhibitors, inhibits, tripeptidyl, peptidase, II, Proteases, Proteinases, Cholecystokinin, Other, Non-selective, CCK, 1323, Tocris Bioscience
3 Citations for Butabindide oxalate
Citations are publications that use Tocris products. Selected citations for Butabindide oxalate include:
Lorente et al (2011) Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells. J Biol Chem 286 38054 PMID: 21914809
Duensing et al (2010) Tripeptidyl Peptidase II Is Required for c-MYC-Induced Centriole Overduplication and a Novel Therapeutic Target in c-MYC-Associated Neoplasms. Genes Cancer 1 883 PMID: 21647238
Dasgupta et al (2014) Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells. PLoS One 9 e103604 PMID: 25079948
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