GR 144053 trihydrochloride

Cat. No. 1263 1 Citation Submit a Review Datasheet / COA / SDS

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Description: Glycoprotein IIb/IIIa (integrin α_IIbβ₃) receptor antagonist. Antithrombotic

Chemical Name: 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride

Purity: ≥99% (HPLC)

Datasheet

Citations (1)

Reviews

Literature (2)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for GR 144053 trihydrochloride

GR 144053 trihydrochloride is a potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC₅₀ = 37 nM). Orally active and highly effective at inhibiting thrombus formation in vivo.

Technical Data for GR 144053 trihydrochloride

M. Wt	454.83
Formula	C₁₈H₂₇N₅O₂.3HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	1215333-48-4
PubChem ID	107895
InChI Key	GFZHNFOGCMEYTA-UHFFFAOYSA-N
Smiles	Cl.Cl.Cl.NC(=N)C1=CC=C(C=C1)N1CCN(CC1)C1CCN(CC(O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GR 144053 trihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	45.48	100

Preparing Stock Solutions for GR 144053 trihydrochloride

The following data is based on the product molecular weight 454.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.2 mL	10.99 mL	21.99 mL
5 mM	0.44 mL	2.2 mL	4.4 mL
10 mM	0.22 mL	1.1 mL	2.2 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Product Datasheets for GR 144053 trihydrochloride

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for GR 144053 trihydrochloride

References are publications that support the biological activity of the product.

Eldred et al (1994) Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists: identification of 4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid as a long-acting, broad spectrum antithrombotic agent. J.Med.Chem. 37 3882 PMID: 7966149

Matsuno et al (1997) GR 144053, a fibrinogen receptor antagonist, enhances the suppression of neointima formation by losartan, an angiotensin II receptor antagonist, in the injured carotid artery of hamster. Br.J.Pharmacol. 122 1099 PMID: 9480031

Matsuno et al (1999) Comparative antiplatelet effects of aspirin, vapiprost and GR 144053, a GPIIb/IIIa antagonist with special reference to the role of platelet microaggregates. Br.J.Pharmacol. 127 1129 PMID: 10455258

If you know of a relevant reference for GR 144053 trihydrochloride, please let us know.

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1 Citation for GR 144053 trihydrochloride

Citations are publications that use Tocris products. Selected citations for GR 144053 trihydrochloride include:

Pavlou et al (2023) CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death. Sci.Rep. 13 3934 PMID: 36894612

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.