Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSDM25N hydrochloride
Discontinued Product
1410 has been discontinued.
Description: High affinity and selective non-peptide δ antagonist; also inhibits dengue virus replication
Chemical Name: (4bS,8R,8aS,14bR)-5,6,7,8,14,14b-Hexahydro-7-(2-methyl-2-propenyl)-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for SDM25N hydrochloride
SDM25N hydrochloride is a high affinity and highly selective non-peptide δ receptor antagonist (Ki values are 4.7, 3800 and 7900 nM for δ, κ and μ receptors respectively). More selective than naltrindole (Cat. No. 0740). Also inhibits Dengue virus replication.
Technical Data for SDM25N hydrochloride
| M. Wt | 450.96 |
| Formula | C26H26N2O3.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 342884-71-3 |
| PubChem ID | 90479789 |
| InChI Key | QLLCUVACGPLGAX-IDRHMUJXSA-N |
| Smiles | Cl.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC(C)=C)[C@]([H])(C4)[C@]1(O)CC1=C2NC2=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SDM25N hydrochloride
References for SDM25N hydrochloride
References are publications that support the biological activity of the product.
McLamore et al (2001) Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7:2 ',3 '-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. J.Med.Chem. 44 1471 PMID: 11311071
Sprokholt et al (2017) RIG-I-like receptor triggering by Dengue virus drives dendritic cell immune activation and TH1 differentiation. J.Immunol. PMID: 28507028
View Related Products by Target
View Related Products by Product Action
Keywords: SDM25N hydrochloride, SDM25N hydrochloride supplier, Potent, selective, non-peptide, δ-opioid, delta-opioid, antagonist, DOP, Receptors, OP1, dengue, virus, antiviral, Delta, Opioid, Flaviviruses, 1410, Tocris Bioscience
3 Citations for SDM25N hydrochloride
Citations are publications that use Tocris products. Selected citations for SDM25N hydrochloride include:
Ong et al (2015) Prolonged mor. treatment alters δ opioid receptor post-internalization trafficking. Br J Pharmacol 172 615 PMID: 24819092
Sprokholt et al (2017) RIG-I-like receptor triggering by Dengue virus drives dendritic cell immune activation and TH1 differentiation. J.Immunol. 198 4764 PMID: 28507028
van Cleef et al (2013) Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication. Antiviral Res. 99 165 PMID: 23735301
Reviews for SDM25N hydrochloride
There are currently no reviews for this product. Be the first to review SDM25N hydrochloride and earn rewards!
Have you used SDM25N hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.