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Submit ReviewArvanil
Description: Potent CB1 agonist; also anandamide transport inhibitor and TRPV1 agonist
Chemical Name: N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide
Purity: ≥98% (HPLC)
Biological Activity for Arvanil
Arvanil is a cannabinoid CB1 and vanilloid TRPV1 (VR1) agonist (Ki values are 0.5 and 0.3 μM respectively). Also inhibits the anandamide transporter (IC50 = 3.6 μM). Analgesic, vasodilatory and anti-inflammatory in vivo.
Technical Data for Arvanil
| M. Wt | 439.64 |
| Formula | C28H41NO3 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 128007-31-8 |
| PubChem ID | 6449767 |
| InChI Key | QVLMCRFQGHWOPM-ZKWNWVNESA-N |
| Smiles | O=C(NCC1=CC=C(O)C(OC)=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Arvanil
References for Arvanil
References are publications that support the biological activity of the product.
Di Marzo et al (2000) Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide. Eur.J.Pharmacol. 406 363 PMID: 11040343
Melck et al (1999) Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 receptors. Biochem.Biophys.Res.Commun. 262 275 PMID: 10448105
Szallasi and Di Marzo (2000) New perspectives on enigmatic vanilloid receptors. Trends Neurosci. 23 491 PMID: 11006466
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Keywords: Arvanil, Arvanil supplier, Potent, CB1, TRPV1, VR1, agonists, anandamide, transporters, inhibitors, inhibits, AMT, Cannabinoids, Monoamine, Neurotransmitter, Receptors, Vanillioid, TRPV, TRP, Channels, Transient, Receptor, Potential, cb1r, Cannabinoid, Transporters, 1354, Tocris Bioscience
Citations for Arvanil
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Currently there are no citations for Arvanil.
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Literature in this Area
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