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Submit ReviewFR 236924
Description: Selective PKCε activator
Alternative Names: DCP-LA
Chemical Name: 2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid
Purity: ≥99% (HPLC)
Biological Activity for FR 236924
Selective PKCε activator that displays > 7-fold selectivity over other PKC isozymes. Stimulates glutamate release via presynaptic α7 nicotinic receptors on glutamatergic terminals in vitro and enhances cognition in vivo. Brain penetrant.
Technical Data for FR 236924
| M. Wt | 308.5 |
| Formula | C20H36O2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 28399-31-7 |
| PubChem ID | 9904718 |
| InChI Key | CONYTTFKIUJZOF-UHFFFAOYSA-N |
| Smiles | CCCCCC(C2)C2CC1C(CCCCCCCC(O)=O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for FR 236924
References for FR 236924
References are publications that support the biological activity of the product.
Yamamoto et al (2005) The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancgng activity of presynaptic α7 acetylcholine receptors on the glutamatergic terminals. Neuroscience 130 207 PMID: 15561436
Kanno et al (2006) The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site. J.Lipid Res. 47 1146 PMID: 16520488
Tanaka and Nishizaki (2003) The newly synthesized linoleic acid derivative FR236924 induces a long lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. Bioorg.Med.Chem.Letts. 13 1037
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Citations for FR 236924
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