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Submit ReviewFK 409
Discontinued Product
This product has been withdrawn from sale and is superseded by DETA NONOate (Cat. No. 6077)
Description: NO donor
Alternative Names: NOR-3,(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
Chemical Name: (2E,3E)-4-Ethyl-2-(hydroxyimino)-5-nitro-3-hexenamide
Purity: ≥98% (HPLC)
Biological Activity for FK 409
NO donor; exhibits vasorelaxant (EC50 = 3.9 nM) and antiplatelet activities (IC50 = 4.9 μM). Cell permeable.
Technical Data for FK 409
| M. Wt | 215.21 |
| Formula | C8H13N3O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 138472-01-2 |
| PubChem ID | 6437875 |
| InChI Key | MZAGXDHQGXUDDX-AGLLBGTNSA-N |
| Smiles | CC(/C(CC)=C/C(C(N)=O)=N\O)[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for FK 409
References for FK 409
References are publications that support the biological activity of the product.
Fukuyama et al (1997) Structure-activity relationships of spontaneous nitric oxide releasers, FK409 and its derivatives. J.Pharmacol.Exp.Ther. 282 236 PMID: 9223559
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Keywords: FK 409, FK 409 supplier, FK409, NO, donors, nitric, oxide, vasorelaxant, cell, permeable, NOR-3, (±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide, Donors, /, Precursors, ROS, 3105, Tocris Bioscience
1 Citation for FK 409
Citations are publications that use Tocris products. Selected citations for FK 409 include:
Cortés-Montero et al (2019) The axonal motor neuropathy-related HINT1 protein is a zinc- and calmodulin-regulated cysteine SUMO protease. Antioxid Redox Signal PMID: 31088288
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