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Submit ReviewScopolamine hydrobromide
Description: Non-selective muscarinic antagonist
Chemical Name: (α,S)-α-(Hydroxymethyl)benzeneacetic acid (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester hydrobromide
Purity: ≥99% (HPLC)
Biological Activity for Scopolamine hydrobromide
Scopolamine hydrobromide is a non-selective muscarinic antagonist. Widely used clinically to treat motion sickness.
Technical Data for Scopolamine hydrobromide
| M. Wt | 384.27 |
| Formula | C17H21NO4.HBr |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 114-49-8 |
| PubChem ID | 45073445 |
| InChI Key | WMRMIRRDPBKNMY-ZEECNFPPSA-N |
| Smiles | O=C([C@@H]([C@]3=CC=CC=C3)CO)O[C@H]1C[C@H]4[C@H](O2)[C@H]2[C@H](N4C)C1.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Scopolamine hydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 38.43 | 100 | |
| DMSO | 19.21 | 50 |
Preparing Stock Solutions for Scopolamine hydrobromide
The following data is based on the product molecular weight 384.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.6 mL | 13.01 mL | 26.02 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.2 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.6 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets for Scopolamine hydrobromide
References for Scopolamine hydrobromide
References are publications that support the biological activity of the product.
Jones and Shannon (2000) Effects of scopol. in comparison with apomor. and phencyclidine on prepulse inhibition in rats. Eur.J.Pharmacol. 391 105 PMID: 10720641
Nakao et al (1999) Cerebral blood flow responses to somatosensory stimulation are unaffected by scopol. in unanesthetized rat. J.Pharmacol.Exp.Ther. 290 929 PMID: 10411611
Parkes (1965) An examination of central actions characteristic of scopolamine: comparison of central and peripheral activity in scopolamine, atr. and some synthetic basic esters. Psychopharmacologia 7 1 PMID: 5830966
If you know of a relevant reference for Scopolamine hydrobromide, please let us know.
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Keywords: Scopolamine hydrobromide, Scopolamine hydrobromide supplier, Non-Selective, muscarinic, antagonist, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, 1414, Tocris Bioscience
17 Citations for Scopolamine hydrobromide
Citations are publications that use Tocris products. Selected citations for Scopolamine hydrobromide include:
Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788
Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission Scientific Reports 6 37834 PMID: 27886263
Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Front Behav Neurosci 4 PMID: 25723967
Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Proc Natl Acad Sci U S A 9 284 PMID: 26578914
Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. J Neurosci 112 8124 PMID: 26080439
Field et al (2012) Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium. J Neurosci 32 6288 PMID: 22553034
Marcott et al (2014) Phasic DA release drives rapid activation of striatal D2-receptors. Neuron 84 164 PMID: 25242218
Higley et al (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6 e19155 PMID: 21544206
Chuhma et al (2014) DA neurons control striatal cholinergic neurons via regionally heterogeneous DA and glutamate signaling. Elife 81 901 PMID: 24559678
Delcourte et al (2020) Astroglia in lateral habenula is essential for antidepressant efficacy of light. BioRXiv - not yet peer reviewed
Bali et al (2015) Differential effects of α7 nicotinic receptor agonist PHA-543613 on spatial memory performance of rats in two distinct pharmacological dementia models. Brain Behav Res 278 404 PMID: 25447295
Chuhma et al (2009) DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience 164 1068 PMID: 19729052
Bali et al (2019) Cognitive enhancer effects of low Mem. doses are facilitated by an alpha7 nicotinic acetylcholine receptor agonist in scopolamine-induced amnesia in rats. Front Pharmacol 10 73 PMID: 30804787
Lecrux et al (2017) Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation. J Neurosci 37 1518 PMID: 28069927
Chou et al (2018) (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology 139 1 PMID: 29953886
Cai & Ford (2018) DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate. Cell Rep 25 3148 PMID: 30540946
Herrera-Rincon et al (2017) The brain is required for normal muscle and nerve patterning during early Xenopus development. Nat Commun 8 587 PMID: 28943634
Do you know of a great paper that uses Scopolamine hydrobromide from Tocris? Please let us know.
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