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Submit ReviewNoladin ether
Description: Endogenous agonist for CB1 and GPR55
Alternative Names: HU 310,2-Arachidonyl glycerol ether
Chemical Name: 2-[(5Z,8Z,11Z,14Z)-Eicosatetraenyloxy]-1,3-propanediol
Biological Activity for Noladin ether
Noladin ether is an endogenous agonist for the GPR55 and CB1 receptors (EC50 values are 10 and 37 nM respectively) that displays selectivity over CB2 receptors (Ki values are 21.2 nM and > 3mM at CB1 and CB2 respectively). Causes sedation, hypothermia, intestinal immobility and mild antinociception in vivo. Attenuates sensory neurotransmission in rat mesenteric arteries via GPR55.
Technical Data for Noladin ether
| M. Wt | 364.57 |
| Formula | C23H40O3 |
| Storage | Desiccate at -20°C |
| CAS Number | 222723-55-9 |
| PubChem ID | 6483057 |
| InChI Key | CUJUUWXZAQHCNC-DOFZRALJSA-N |
| Smiles | CCCCC\C=C/C\C=C/C/C=C\C/C=C\CCCCOC(CO)CO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Noladin ether
References for Noladin ether
References are publications that support the biological activity of the product.
Duncan et al (2004) Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 Gi/o linked receptor. Br.J.Pharmacol. 142 509 PMID: 15148262
Hanus et al (2001) 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc.Natl.Acad.Sci.U.S.A. 98 3662 PMID: 11259648
Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302
Sugiura et al (1999) Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. J.Biol.Chem. 274 2794 PMID: 9915812
Suhara et al (2000) Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues. Chem.Pharm.Bull. 48 903 PMID: 10923815
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Keywords: Noladin ether, Noladin ether supplier, Endogenous, agonists, GPR55, CB1, Cannabinoids, Receptors, HU310, cb1r, HU, 310, 2-Arachidonyl, glycerol, ether, 1411, Tocris Bioscience
1 Citation for Noladin ether
Citations are publications that use Tocris products. Selected citations for Noladin ether include:
Ho and Randall (2007) Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. PLoS One 150 641 PMID: 17245358
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