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Submit Review(-)-Cotinine
Discontinued Product
3110 has been discontinued.
View all Nicotinic Receptors (Non-selective) products.
Description: Major metabolite of nicotine
Chemical Name: (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
Purity: ≥99% (HPLC)
Biological Activity for (-)-Cotinine
Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model.
Technical Data for (-)-Cotinine
| M. Wt | 176.22 |
| Formula | C10H12N2O |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 486-56-6 |
| PubChem ID | 854019 |
| InChI Key | UIKROCXWUNQSPJ-VIFPVBQESA-N |
| Smiles | CN(C(CC2)=O)[C@@H]2[C@]1=CC=CN=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (-)-Cotinine
References for (-)-Cotinine
References are publications that support the biological activity of the product.
Buccafusco and Terry (2003) The potential role of cotinine in the cognitive and neuroprotective actions of nicotine. Life Sci. 72 2931 PMID: 12706481
Terry et al (2005) Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition. CNS Drug Rev. 11 229 PMID: 16389292
O'Leary et al (2008) Cotinine selectively activates a subpopulation of α3/α6β2 nicotinic receptors in monkey striatum. 325 646 PMID: 18305015
Echeverria et al (2011) Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice. J.Alzheimers Dis. 23 1 PMID: 20930295
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Keywords: Cotinine, Cotinine supplier, metabolite, nicotine, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, nAChR, (Non-selective), 3110, Tocris Bioscience
Citations for (-)-Cotinine
Citations are publications that use Tocris products.
Currently there are no citations for (-)-Cotinine.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.