Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Reviewd[Leu4,Lys8]-VP
Description: Selective V1B agonist
Biological Activity for d[Leu4,Lys8]-VP
d[Leu4,Lys8]-VP is a selective vasopressin V1B receptor agonist (Ki values are 0.16, 64, 100 and 3800 nM for V1B, oxytocin, V2 and V1A receptors respectively). Displays weak antidiuretic, vasopressor and in vitro oxytocic activities.
Technical Data for d[Leu4,Lys8]-VP
| M. Wt | 1026.2 |
| Formula | C47H67N11O11S2 |
| Sequence |
XYFLNCPKG (Modifications: X = Mpr, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6) |
| Storage | Store at -20°C |
| CAS Number | 42061-33-6 |
| PubChem ID | 44419030 |
| InChI Key | QGZMLGLFLYCDQT-PEAOEFARSA-N |
| Smiles | CC(C)C[C@@H]1NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for d[Leu4,Lys8]-VP
References for d[Leu4,Lys8]-VP
References are publications that support the biological activity of the product.
Pena et al (2007) Design and synthesis of the frist selective agonists for the rat vasopressin V1b receptor: based on modifications of deamino-[cys1]arginine vasopressin at positions 4 and 8. J.Med.Chem. 50 835 PMID: 17300166
Pena et al (2007) Pharmacological and physiological characterization of d[Leu4,Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology 148 4136 PMID: 17495006
View Related Products by Target
View Related Products by Product Action
Keywords: d[leu4,Lys8]-VP, d[leu4,Lys8]-VP supplier, Selective, V1b, agonists, V2, Receptors, Vasopressin, 3127, Tocris Bioscience
1 Citation for d[Leu4,Lys8]-VP
Citations are publications that use Tocris products. Selected citations for d[Leu4,Lys8]-VP include:
Leroy et al (2018) A circuit from hippocampal CA2 to lateral septum disinhibits social aggression. Nature 564 213 PMID: 30518859
Reviews for d[Leu4,Lys8]-VP
There are currently no reviews for this product. Be the first to review d[Leu4,Lys8]-VP and earn rewards!
Have you used d[Leu4,Lys8]-VP?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.