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Submit ReviewBU 224 hydrochloride
Description: Potent, selective I2 ligand. Putative antagonist
Chemical Name: 2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride
Biological Activity for BU 224 hydrochloride
BU 224 hydrochloride is a high affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). Putative I2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.
Technical Data for BU 224 hydrochloride
| M. Wt | 233.7 |
| Formula | C12H11N3.HCl |
| Storage | Desiccate at RT |
| CAS Number | 205437-64-5 |
| PubChem ID | 11957470 |
| InChI Key | DDFHQXAQWZWRSQ-UHFFFAOYSA-N |
| Smiles | Cl.C1CN=C(N1)C1=NC2=CC=CC=C2C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BU 224 hydrochloride
References for BU 224 hydrochloride
References are publications that support the biological activity of the product.
Hudson et al (1999) Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 881 81 PMID: 10415900
MacInnes and Dut (2004) Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway. Br.J.Pharmacol. 143 952 PMID: 15545290
Sanchez-Blasquez et al (2000) Activation of I2-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 130 146 PMID: 10781010
Hudson et al (1994) Affinity and selectivity of BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I2) sites). Br.J.Pharmacol. 112 320P
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Keywords: BU 224 hydrochloride, BU 224 hydrochloride supplier, Potent, selective, I2, ligand, Putative, antagonists, Imidazoline, Receptors, BU224, hydrochloride, 0725, Tocris Bioscience
2 Citations for BU 224 hydrochloride
Citations are publications that use Tocris products. Selected citations for BU 224 hydrochloride include:
Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146 PMID: 10781010
Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423
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