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C-1

Cat. No. 0543 Submit a Review Datasheet / COA / SDS

Discontinued Product

0543 has been discontinued.

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Description: Inhibits PKG, PKA and PKC
Alternative Names: HA 100
Chemical Name: 1-(5-Isoquinolinesulfonyl)piperazine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for C-1

C-1 is a protein kinase inhibitor. Inhibits PKG, PKA and PKC (IC50 values are 4, 8 and 12 μM, respectively). Widely used as a ROCK inhibitor. Increases efficiency of human fibroblast reprogramming with PD 0325901 (Cat.No 4192), CHIR 99021 (Cat.No 4432), A 83-01 (Cat.No 2939) and hLIF. Improves survival of human pluripotent stem cells in culture.

Technical Data for C-1

M. Wt 277.34
Formula C13H15N3O2S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 84468-24-6
PubChem ID 3545
InChI Key UPTYCYWTFGTCCG-UHFFFAOYSA-N
Smiles O=S(=O)(N1CCNCC1)C1=C2C=CN=CC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for C-1

References are publications that support the biological activity of the product.

Gerard et al (1986) Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidation metabolism by various agonists. J.Clin.Invest. 77 61 PMID: 3003155

Yu et al (2011) Efficient feeder-free episomal reprogramming with small molecules. PLoS.One. 6 e17557 PMID: 21390254

Chen et al (2011) Chemically defined conditions for human iPSC derivation and culture. Nat.Methods 8 424 PMID: 21478862

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Citations for C-1

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