Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide
Description: Potent, selective NPY Y5 agonist
Purity: ≥95% (HPLC)
Biological Activity
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide is a potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM). Stimulates food intake in vivo.
Technical Data
| M. Wt | 4207.67 |
| Formula | C183H281N57O54S2 |
| Sequence |
GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY (Modifications: X = Aib, Tyr-36 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 313988-89-5 |
| PubChem ID | 90479787 |
| InChI Key | DXMCMRQWOIRILO-VRGOUOKESA-N |
| Smiles | [H]NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NC(C)(C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Cabrele et al (2000) The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats. J.Biol.Chem. 275 36043 PMID: 10944518
Dumont et al (2005) BODIPY®-conjugated neuropeptide Y ligands: new fluorescent tools to tag Y1, Y2, Y4 and Y5 receptor subtypes. Br.J.Pharmacol. 146 1069 PMID: 16231000
View Related Products by Target
View Related Products by Product Action
Keywords: [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide, [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide supplier, Potent, selective, neuropeptide, Y, Y5, agonists, Neuropeptide, Receptors, neuropeptides, NPY, 1365, Tocris Bioscience
Citations for [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide
Citations are publications that use Tocris products.
Currently there are no citations for [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide.
Reviews for [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide
There are currently no reviews for this product. Be the first to review [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide and earn rewards!
Have you used [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.