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Submit ReviewSwainsonine
Description: Inhibitor of α-mannosidase II
Chemical Name: (1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol
Biological Activity for Swainsonine
Swainsonine is an inhibitor of α-mannosidase II which inhibits glycoprotein processing. Displays anticancer and immune modulatory properties.
Technical Data for Swainsonine
| M. Wt | 173.21 |
| Formula | C8H15NO3 |
| Storage | Store at -20°C |
| CAS Number | 72741-87-8 |
| PubChem ID | 51683 |
| InChI Key | FXUAIOOAOAVCGD-WCTZXXKLSA-N |
| Smiles | O[C@@H]2[C@H](O)CN1CCC[C@@H](O)[C@@]12[H] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Swainsonine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.66 | 50 |
Preparing Stock Solutions for Swainsonine
The following data is based on the product molecular weight 173.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 11.55 mL | 57.73 mL | 115.47 mL |
| 2.5 mM | 2.31 mL | 11.55 mL | 23.09 mL |
| 5 mM | 1.15 mL | 5.77 mL | 11.55 mL |
| 25 mM | 0.23 mL | 1.15 mL | 2.31 mL |
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Product Datasheets for Swainsonine
References for Swainsonine
References are publications that support the biological activity of the product.
Tulsiani et al (1982) Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of golgi mannosidase II. J.Biol.Chem. 257 7936 PMID: 6806288
Olden et al (1991) The potential importance of swainsonine in therapy for cancers and immunology. Pharmacol.Ther. 50 285 PMID: 1754603
Sun et al (2007) Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine. Phytomedicine 14 353 PMID: 17097281
If you know of a relevant reference for Swainsonine, please let us know.
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Keywords: Swainsonine, Swainsonine supplier, inhibitors, inhibits, α-mannosidase, alpha-mannosidase, II, Glycosylases, Carbohydrate, Metabolism, 3208, Tocris Bioscience
3 Citations for Swainsonine
Citations are publications that use Tocris products. Selected citations for Swainsonine include:
Skrenkova et al (2018) N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors. Front Mol Neurosci 11 188 PMID: 29915530
Tareen et al (2014) Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells. Mol Ther 22 575 PMID: 24419083
Nacev et al (2011) The antifungal drug itracon. inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. J Biol Chem 286 44045 PMID: 22025615
Do you know of a great paper that uses Swainsonine from Tocris? Please let us know.
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