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Submit ReviewAGK 2
Description: Selective SIRT2 inhibitor
Chemical Name: 2-Cyano-3-[[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Purity: ≥98% (HPLC)
Biological Activity for AGK 2
Selective inhibitor of SIRT2 (IC50 = 3.5 μM). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μM. Reduces α-synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.
Technical Data for AGK 2
| M. Wt | 434.27 |
| Formula | C23H13Cl2N3O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 304896-28-4 |
| PubChem ID | 2130404 |
| InChI Key | SVENPFFEMUOOGK-SDNWHVSQSA-N |
| Smiles | O=C(/C(C#N)=C/C3=CC=C(C4=C(Cl)C=CC(Cl)=C4)O3)NC2=CC=CC1=NC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AGK 2
References for AGK 2
References are publications that support the biological activity of the product.
Outeiro et al (2007) Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease. Science 317 516 PMID: 17588900
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Keywords: AGK 2, AGK 2 supplier, Selective, SIRT2, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, AGK2, Class, III, HDACs, (Sirtuins), 3233, Tocris Bioscience
3 Citations for AGK 2
Citations are publications that use Tocris products. Selected citations for AGK 2 include:
Newton et al (2014) Is SIRT2 required for necroptosis? Nature 506 E4 PMID: 24572428
Snider et al (2013) Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. Adipocyte 200 241 PMID: 23358244
Xu et al (2013) Temporal analysis of protein lysine acetylation during adipocyte differentiation. J Pharmacol Exp Ther 2 33 PMID: 23700550
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