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Submit ReviewCastanospermine
Description: Glucosidases α and β inhibitor
Chemical Name: [1S-(1α,6β,7α,8β,8aβ)]-Octahydro-1,6,7,8-indolizinetetrol
Biological Activity for Castanospermine
Castanospermine is a potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.
Technical Data for Castanospermine
| M. Wt | 189.21 |
| Formula | C8H15NO4 |
| Storage | Store at RT |
| CAS Number | 79831-76-8 |
| PubChem ID | 54445 |
| InChI Key | JDVVGAQPNNXQDW-TVNFTVLESA-N |
| Smiles | [H][C@]12[C@@H](O)CCN1C[C@H](O)[C@@H](O)[C@@H]2O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Castanospermine
References for Castanospermine
References are publications that support the biological activity of the product.
Gruters et al (1987) Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature 330 74 PMID: 2959866
Saul et al (1984) Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases. Arch.Biochem.Biophys. 230 668 PMID: 6424575
Welker et al (1987) Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proc.Natl.Acad.Sci.U.S.A. 84 8120 PMID: 2825177
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Keywords: Castanospermine, Castanospermine supplier, β-glucosidases, beta-glucosidases, b-glucosidase, inhibitors, inhibits, a-Glucosidase, α-glucosidase, alpha-glucosidase, Glycosylases, Carbohydrate, Metabolism, 0759, Tocris Bioscience
1 Citation for Castanospermine
Citations are publications that use Tocris products. Selected citations for Castanospermine include:
Nacev et al (2011) The antifungal drug itracon. inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. J Biol Chem 286 44045 PMID: 22025615
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