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TCS PrP Inhibitor 13

Cat. No. 3238 2 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

3238 has been discontinued.

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Description: Antiprion agent; inhibits PrPSc accumulation
Chemical Name: 2,4-Dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for TCS PrP Inhibitor 13

TCS PrP Inhibitor 13 is an antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). Also reduces PrP expression and decreases proliferation and survival in schwannoma cell lines.

Technical Data for TCS PrP Inhibitor 13

M. Wt 281.27
Formula C15H11N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 34320-83-7
PubChem ID 2750328
InChI Key FDAVFKZPGQEGDX-UHFFFAOYSA-N
Smiles O=C(C2)N(C3=CC=CC=C3)N=C2C1=CC=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for TCS PrP Inhibitor 13

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for TCS PrP Inhibitor 13

References are publications that support the biological activity of the product.

Kimata et al (2007) New series of antiprion compounds: pyrazolone derivatives have potent activity of inhibiting protease-resistant prion protein accumulation. J.Med.Chem. 50 5053 PMID: 17850126

Provenzano et al (2017) Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 36 6132 PMID: 28692055

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Keywords: TCS PrP Inhibitor 13, TCS PrP Inhibitor 13 supplier, Antiprion, agent, potently, inhibits, inhibitors, PrP-res, accumulation, Prion, Protein, Neuronal, Metabolism, TCSPrP, Inhibitor13, 3238, Tocris Bioscience

2 Citations for TCS PrP Inhibitor 13

Citations are publications that use Tocris products. Selected citations for TCS PrP Inhibitor 13 include:

Safavifar et al (2019) Augmented cAMP Signaling by Co-Administration of Resveratrol and Curcumin: A Cellular Biosensor Kinetic Assessment. Iran J Public Health 48 1310 PMID: 31497553

Provenzano et al (2017) Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. PMID: 28692055

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Pathways for TCS PrP Inhibitor 13

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.