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Submit ReviewL-CCG-lll
Description: Potent, competitive glutamate uptake inhibitor
Alternative Names: (2S,3S,4R)-CCG
Chemical Name: (2S,1'S,2'R)-2-(Carboxycyclopropyl)glycine
Biological Activity for L-CCG-lll
Potent and competitive inhibitor of both glial and neuronal uptake of glutamate, aspartate and cysteate.
Technical Data for L-CCG-lll
| M. Wt | 159.14 |
| Formula | C6H9NO4 |
| Storage | Store at RT |
| CAS Number | 117857-95-1 |
| PubChem ID | 5310957 |
| InChI Key | GZOVEPYOCJWRFC-NUNKFHFFSA-N |
| Smiles | N[C@]([H])(C(O)=O)[C@@]([H])(C1)[C@@]([H])1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L-CCG-lll
Certificate of Analysis is currently unavailable on-line.
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References for L-CCG-lll
References are publications that support the biological activity of the product.
Kawai et al (1992) 2-Carboxycyclopropyl)glycine: binding, neurotoxicity and induction of intracellular free Ca2+ increase. Eur.J.Pharmacol. 211 195 PMID: 1319341
Nakamura et al (1993) (2S,3S,4R)-2-(Carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology 32 833 PMID: 7901789
Shinozaki et al (1989) Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord. Br.J.Pharmacol. 98 1213 PMID: 2692753
Yamashita et al (1995) Inhibition by folded isomers of L-2-(carboxycyclopropyl)glycine of glutamate uptake via the human glutamate transporter hGluT-I. Eur.J.Pharmacol. 289 387 PMID: 7621914
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Keywords: L-CCG-lll, L-CCG-lll supplier, Potent, competitive, reuptake, inhibitors, inhibits, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, (2S,3S,4R)-CCG, 0332, Tocris Bioscience
Citations for L-CCG-lll
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Literature in this Area
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Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.