Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewATP disodium salt
Description: P2 agonist
Chemical Name: Adenosine 5'-triphosphate disodium salt
Purity: ≥99% (HPLC)
Biological Activity for ATP disodium salt
ATP disodium salt is a P2 purinoceptor agonist.
Technical Data for ATP disodium salt
| M. Wt | 551.14 |
| Formula | C10H14N5Na2O13P3 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 987-65-5 |
| PubChem ID | 13803 |
| InChI Key | TTWYZDPBDWHJOR-IDIVVRGQSA-L |
| Smiles | O[C@@H]1[C@@H](COP(OP(OP(O)([O-])=O)([O-])=O)(O)=O)O[C@@H](N3C2=NC=NC(N)=C2N=C3)[C@@H]1O.[Na+].[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ATP disodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 55.11 | 100 |
Preparing Stock Solutions for ATP disodium salt
The following data is based on the product molecular weight 551.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.81 mL | 9.07 mL | 18.14 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.63 mL |
| 10 mM | 0.18 mL | 0.91 mL | 1.81 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for ATP disodium salt
References for ATP disodium salt
References are publications that support the biological activity of the product.
Gordon (1986) Extracellular ATP: effects, sources and fate. Biochem.J 233 309 PMID: 3006665
Guilbert et al (1998) Dependence of P2-nucleotide receptor agonist-mediated endothelium-indepdent relaxation on ectonucleotidase acticity and A2A-receptors in rat portal vein. Br.J.Pharm. 123 1732
Burnstock and Kenned (2006) Historical review: ATP as a neurotransmitter. Trends Pharm.Sci. 27 16
If you know of a relevant reference for ATP disodium salt, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ATP disodium salt, ATP disodium salt supplier, P2, purinergic, agonists, P2X, Receptors, Purinergic, P2Y, purinoceptors, Adenosine, 5'-triphosphate, disodium, salt, 3245, Tocris Bioscience
3 Citations for ATP disodium salt
Citations are publications that use Tocris products. Selected citations for ATP disodium salt include:
Hannedouche et al (2013) Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. Purinergic Signal 288 27434 PMID: 23940034
Taheri et al (2017) Diversity of Evoked Astrocyte Ca2+ Dynamics Quantified through Experimental Measurements and Mathematical Modeling. Front Syst Neurosci 11 79 PMID: 29109680
Song et al (2015) Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury. Neuropharmacology 11 203 PMID: 25682129
Do you know of a great paper that uses ATP disodium salt from Tocris? Please let us know.
Reviews for ATP disodium salt
Average Rating: 5 (Based on 5 Reviews.)
Have you used ATP disodium salt?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
great to use for the synthesis of complexes and for its use in biological assays.
By
Anonymous on 07/02/2019
Species: Human
I used it to prepare a complex at 1mM concentration.
The product is highly soluble in water thus the most suitable solvent for it to use.
Kinase Assay ATP Kinetics.
By
Brian Englar on 02/06/2019
Assay Type: In Vitro
Species: Human
Used this ATP for kinase assays with IRAK4 and a TAK1 inhibitor to determine Km and Vmax. Worked well with no issues and can freeze thaw with no issues.
Great for kinase assays and kinetics.
By
Scott Scarneo on 02/06/2019
Assay Type: In Vitro
Species: Human
I used this product for a kinase assay to look at enzyme kinetics. Worked great and was pure with no issues on solubility or contamination.
Exreacellular ATP stimulates IL-1b production in macrophages.
By
Chintan Koyani on 10/23/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Macrophages
RAW macrophages were incubated with ATP (5 mM) for 4 h to follow IL-1b mRNA expression using qPCR. ATP treatment induced inflammatory signalling in macrophages most likely via P2 receptor.
P2 agonist.
By
Anonymous on 05/17/2018
Assay Type: Ex Vivo
Species: Mouse
ATP, as expected, activates multiple P2 receptor responses, in cell culture and in brain slices.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.