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Submit ReviewCeramide
Description: Ser/Thr protein phosphatase activator
Chemical Name: N-Acetylsphingosine
Biological Activity for Ceramide
Ceramide is a potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro.
Compound Libraries for Ceramide
Ceramide is also offered as part of the Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for Ceramide
| M. Wt | 341.53 |
| Formula | C20H39NO3 |
| Storage | Desiccate at -20°C |
| CAS Number | 3102-57-6 |
| PubChem ID | 5497136 |
| InChI Key | BLTCBVOJNNKFKC-QUDYQQOWSA-N |
| Smiles | OC[C@@](NC(C)=O)([H])[C@H](O)/C([H])=C([H])/CCCCCCCCCCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ceramide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 34.15 | 100 | |
| DMSO | 34.15 | 100 |
Preparing Stock Solutions for Ceramide
The following data is based on the product molecular weight 341.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.93 mL | 14.64 mL | 29.28 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.86 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.93 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
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Product Datasheets for Ceramide
References for Ceramide
References are publications that support the biological activity of the product.
Dobowsky and Hannun (1992) Ceramide stimulates a cytosolic protein phosphatase. J.Biol.Chem. 267 5048 PMID: 1312082
Kim et al (1991) Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-IF.. J.Biol.Chem. 266 484 PMID: 1845977
Quintans et al (1994) Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem.Biophys.Res.Commun. 202 710 PMID: 8048941
Xie and Johnson (1997) Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I. J.Neurochem. 69 1020 PMID: 9282924
If you know of a relevant reference for Ceramide, please let us know.
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Keywords: Ceramide, Ceramide supplier, Ser/Thr, protein, phosphatase, activators, Protein, Phosphatases, 0744, Tocris Bioscience
1 Citation for Ceramide
Citations are publications that use Tocris products. Selected citations for Ceramide include:
Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Pharmacol Biochem Behav 232 44105 PMID: 25300478
Do you know of a great paper that uses Ceramide from Tocris? Please let us know.
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