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Submit ReviewChlormezanone
Description: Positive allosteric modulator of benzodiazepine site
Chemical Name: 2-(4-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one-1,1-dioxide
Purity: ≥99% (HPLC)
Biological Activity for Chlormezanone
Chlormezanone is a anxiolytic and skeletal muscle relaxant that acts at the benzodiazepine site of GABAA receptors.
Compound Libraries for Chlormezanone
Chlormezanone is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Chlormezanone
| M. Wt | 273.73 |
| Formula | C11H12ClNO3S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 80-77-3 |
| PubChem ID | 2717 |
| InChI Key | WEQAYVWKMWHEJO-UHFFFAOYSA-N |
| Smiles | CN1C(C2=CC=C(Cl)C=C2)S(=O)(=O)CCC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Chlormezanone
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.37 | 100 | |
| ethanol | 6.84 | 25 |
Preparing Stock Solutions for Chlormezanone
The following data is based on the product molecular weight 273.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.65 mL | 18.27 mL | 36.53 mL |
| 5 mM | 0.73 mL | 3.65 mL | 7.31 mL |
| 10 mM | 0.37 mL | 1.83 mL | 3.65 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.73 mL |
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Product Datasheets for Chlormezanone
References for Chlormezanone
References are publications that support the biological activity of the product.
Ervin and Cooper (1988) Use of conditioned taste aversion as a conflict model: effects of anxiolytic drugs. J.Pharmacol.Exp.Ther. 245 137 PMID: 2896235
Simiand et al (1989) Comparative study in mice of tetrazepam and other centrally active skeletal muscle relaxants. Arch.Int.Pharmacodyn.Ther. 297 272 PMID: 2567153
Merck Index 12 2155
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Keywords: Chlormezanone, Chlormezanone supplier, Skeletal, muscle, relaxant, GABAA, Receptors, benzodiazepine, PAM, 0456, Tocris Bioscience
Citations for Chlormezanone
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.