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Submit ReviewChlormethiazole hydrochloride
Description: Potentiates GABAA receptor function
Chemical Name: 5-(2-Chloroethyl)-4-methylthiazole hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Chlormethiazole hydrochloride
Chlormethiazole hydrochloride is a sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').
Technical Data for Chlormethiazole hydrochloride
| M. Wt | 198.11 |
| Formula | C6H8ClNS.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 6001-74-7 |
| PubChem ID | 19035073 |
| InChI Key | OFXYKSLKNMTBHK-UHFFFAOYSA-N |
| Smiles | ClCCC1=C(C)N=CS1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Chlormethiazole hydrochloride
References for Chlormethiazole hydrochloride
References are publications that support the biological activity of the product.
Cross et al (1995) The protective action of chloromethiazole against ischaemia induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity. Br.J.Pharmacol. 114 1625 PMID: 7599932
Hewitt and Green (1994) Chloromethiazole, dizocilpine and halope. prevent the degeneration of serotonergic nerve terminals induced by the administration of MDMA ('Ecstasy') to rats. Neuropharmacology 33 1589 PMID: 7539115
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Keywords: Chlormethiazole hydrochloride, Chlormethiazole hydrochloride supplier, Potentiates, GABAA, receptor, function, Receptors, modulators, 0881, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.