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Submit ReviewWWL 70
Description: Potent ABHD6 inhibitor
Chemical Name: N-Methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl carbamic acid ester
Purity: ≥98% (HPLC)
Biological Activity for WWL 70
WWL 70 is a potent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM), an enzyme which catalyzes the hydrolysis of 2-arachidonylglycerol (Cat. No. 1298).
Technical Data for WWL 70
| M. Wt | 437.49 |
| Formula | C27H23N3O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 947669-91-2 |
| PubChem ID | 17759121 |
| InChI Key | QTWNORFUQILKJL-UHFFFAOYSA-N |
| Smiles | O=C(N(C)CC2=CC(C4=CC=NC=C4)=CC=C2)OC1=CC=C(C3=CC=C(C(N)=O)C=C3)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for WWL 70
References for WWL 70
References are publications that support the biological activity of the product.
Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonylglycerol. Chem.Biol. 14 1347 PMID: 18096503
Li et al (2007) A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J.Am.Chem.Soc. 129 9594 PMID: 17629278
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Keywords: WWL 70, WWL 70 supplier, WWL70, potent, ABHD6, inhibitors, αβ-hydrolase, domain, 6, alphabeta-hydrolase, endocannabinoids, 2-arachidonylglycerol, hydrolysis, inhibits, Other, Hydrolases, Cannabinoids, 3252, Tocris Bioscience
1 Citation for WWL 70
Citations are publications that use Tocris products. Selected citations for WWL 70 include:
Tchantchou and Zhang (2013) Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. J Neurotrauma 30 565 PMID: 23151067
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