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Submit ReviewGLP-1 (9-36) amide
Description: Metabolite of GLP-1-(7-36) (Cat. No. 2082)
Alternative Names: Glucagon-like peptide 1 (9-36) amide
Purity: ≥95% (HPLC)
Biological Activity for GLP-1 (9-36) amide
GLP-1 (9-36) amide is a N-terminal truncated metabolite of glucagon-like peptide GLP-1-(7-36) (Cat. No. 2082) formed by dipeptidyl peptidase-IV cleavage. Acts as an antagonist at the human GLP-1 receptor. Inhibits hepatic glucose production in vivo and is a weak insulinotropic agent.
Technical Data for GLP-1 (9-36) amide
| M. Wt | 3089.44 |
| Formula | C140H214N36O43 |
| Sequence |
EGTFTSDVSSYLEGQAAKEFIAWLVKGR (Modification: Arg-28 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 161748-29-4 |
| PubChem ID | 90488821 |
| InChI Key | WPNGPBPCQMDAAD-WRFZDFFOSA-N |
| Smiles | [H]N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GLP-1 (9-36) amide
| Solubility | Soluble to 2 mg/ml in 0.025% acetic acid |
Product Datasheets for GLP-1 (9-36) amide
References for GLP-1 (9-36) amide
References are publications that support the biological activity of the product.
Knudsen and Pridal (1996) Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur.J.Pharmacol. 318 429 PMID: 9016935
Elahi et al (2008) GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide is a glucoregulatory peptide. Obesity 16 1501 PMID: 18421270
Deacon et al (1995) Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J.Clin.Endocrinol.Met. 80 952
If you know of a relevant reference for GLP-1 (9-36) amide, please let us know.
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Citations for GLP-1 (9-36) amide
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.