Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMilnacipran hydrochloride
Description: 5-HT and NA reuptake inhibitor (SNRI)
Chemical Name: (1R*,2S*)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Milnacipran hydrochloride
Milnacipran hydrochloride is a orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α1-adrenergic and 5-HT2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo.
Technical Data for Milnacipran hydrochloride
| M. Wt | 282.81 |
| Formula | C15H22N2O.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 101152-94-7 |
| PubChem ID | 73416954 |
| InChI Key | GIGAIOSMEXBLQA-IBWNGBJLSA-N |
| Smiles | NC[C@@H]1[C@@]([C@](N(CC)CC)=O)([C@]2=CC=CC=C2)C1.NC[C@H]3[C@]([C@](N(CC)CC)=O)([C@]4=CC=CC=C4)C3.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Milnacipran hydrochloride
References for Milnacipran hydrochloride
References are publications that support the biological activity of the product.
Moret et al (1985) Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology 24 1211 PMID: 3005901
Maj et al (2000) Pharmacological effect of milnacipran, a new antidepressant, given repeatedly on the α1-adrenergic and serotonergic 5-HT2A systems. J.Neural.Transm. 107 1345 PMID: 11145008
Suzuki et al (2008) Antiallodynic and antihyperalgesic effect of milnac. in mice with spinal nerve ligation. Anesth.Analg. 106 1309 PMID: 18349211
View Related Products by Target
View Related Products by Product Action
Keywords: Milnacipran hydrochloride, Milnacipran hydrochloride supplier, 5-HT, noradrenaline, reuptake, inhibitors, inhibits, SNRI, Transporters, NET, Adrenergic, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, 3286, Tocris Bioscience
1 Citation for Milnacipran hydrochloride
Citations are publications that use Tocris products. Selected citations for Milnacipran hydrochloride include:
Burnham and Dickenson (2013) The antinociceptive effect of milnac. in the monosodium iodoacetate model of osteoarthritis pain and its relation to changes in descending inhibition. J Pharmacol Exp Ther 344 696 PMID: 23297162
Reviews for Milnacipran hydrochloride
There are currently no reviews for this product. Be the first to review Milnacipran hydrochloride and earn rewards!
Have you used Milnacipran hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.