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Submit ReviewProchlorperazine dimaleate
Description: D2 receptor antagonist; also 5-HT3 and nAChR antagonist
Chemical Name: 2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine dimaleate
Purity: ≥98% (HPLC)
Biological Activity for Prochlorperazine dimaleate
D2 receptor antagonist. Also interacts with 5-HT3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.
Compound Libraries for Prochlorperazine dimaleate
Prochlorperazine dimaleate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Prochlorperazine dimaleate
| M. Wt | 606.09 |
| Formula | C20H24ClN3S.2C4H4O4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 84-02-6 |
| PubChem ID | 5281032 |
| InChI Key | DSKIOWHQLUWFLG-SPIKMXEPSA-N |
| Smiles | O=C(O)/C=C\C(O)=O.ClC4=CC2=C(C=C4)SC1=CC=CC=C1N2CCCN3CCN(C)CC3.O=C(O)/C=C\C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Prochlorperazine dimaleate
References for Prochlorperazine dimaleate
References are publications that support the biological activity of the product.
Lummis and Baker (1997) Radioligand binding and photoaffinity labeling studies show a direct interaction of phenothiazenes at 5-HT3 receptors. Neuropharmacology 36 665 PMID: 9225292
Ghelardini et al (2004) Prochlorperazine induces central antinociception mediated by the muscarinic system. Pharmacol.Res. 50 351 PMID: 15225680
Satoh et al (2005) The antipsychotic and antiemetic drug prochlorper. delays the ventricular repolarization of the in situ canine heart. J.Pharm.Sci. 97 101
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Keywords: Prochlorperazine dimaleate, Prochlorperazine dimaleate supplier, D2, receptor, antagonists, 5-HT3, nAChR, Dopamine, Receptors, serotonin, dopaminergic, Nicotinic, (Non-selective), 3287, Tocris Bioscience
1 Citation for Prochlorperazine dimaleate
Citations are publications that use Tocris products. Selected citations for Prochlorperazine dimaleate include:
Kenny et al (2015) Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. Proc Natl Acad Sci U S A 6 6220 PMID: 25653139
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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